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Leveling Poisonous Concoction

Last Updated: December 8th 2022

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Learn about the key build info and how to increase damage and defense with your stats and gear for the Poisonous Concoction Pathfinder Build.

Leveling section

Key Leveling Notes

This build is incredibly smooth to level once the player reaches level 12 and gains Poisonous Concoction. I recommend pasting this regex into the Search Bar of Vendors selling Armors and Weapons when you go back to town:


Paste this in the vendor window in-game and it highlights four links, movement speed boots, and items with Green-Green-Green (GGG) sockets. This is called a regex filter, and is imperative to finding important items quickly!

Campaign Step By Step

Beginner players should follow Enki's Campaign Progression guide.

The levels listed below are based on speedrunning. Always be greater or equal to the levels listed.

Step-By-Step Poisonous Concoction Skill Gem Progression
Open leveling skill tree in new tab
Act 1
Step 1: Level 2
  • Kill Hillock. Talk to Tarkleigh and choose Caustic Arrow as your reward.
    • Caustic Arrow clears extremely well when paired with Pierce Support
  • Talk to Tarkleigh, click Purchase Items, and copy the following line: -[rgb]-.-|g-g-g|nne
    • Paste it in the vendor window in-game and it highlights four links, movement speed boots, and items with Green-Green-Green (GGG) sockets. This is called a regex filter, and is imperative to finding important items quickly!
  • After this, complete the quests Mercy Mission and Breaking some Eggs.
    • Upon killing Hailrake, hit escape and press EXIT TO CHARACTER SELECT (or type /exit in chat). This saves you a Portal Scroll. Selecting a different log out option puts you in a queue on a league start. This "Return to Town" method is used many times in this guide.
Step 2: Level 4
  • Talk to Nessa and grab: Quicksilver Flask and Mirage Archer Support.
  • Talk to Nessa and Purchase War Banner.
    • War Banner is our first aura. Activating it causes monster deaths to store 50 charges. When released, it gives us the Adrenaline buff for a huge damage boost. This is best used on magic packs, rare monsters, or large packs of regular monsters.
  • Talk to Tarkleigh and grab: Shrapnel Ballista and Dash.
  • Click Purchase Items from Tarkleigh and paste in the regex: -[rgb]-.-|g-g-g|nne
  • Complete the quests Dweller of the Deep and The Caged Brute.
    • Note: you only have to reach the Waypoint in Lower Prison to acquire a gem from the quest.
  • Ideally you have a Green-Green-Green (GGG) item for Caustic Arrow - Pierce Support - Mirage Archer Support
    • If you only have a Green-Green then just link Caustic Arrow to Pierce Support
Step 3: Level 8
  • Reach Lower Prison and use the Waypoint back to town.
  • Talk to Nessa and grab: Lesser Multiple Projectiles Support.
    • You can level this gem in any Green Socket you are currently not using, including in your off-hand!
  • Talk to Tarkleigh to grab your Passive Skillpoint.
  • Click Purchase Items from Tarkleigh and paste in the regex: -[rgb]-.-|g-g-g|nne
  • Go back to Lower Prison, complete the Trial of Ascendancy, and slay Brutus.
  • Start to look for a shield from this point onwards. Any shield will do, but best case scenario find a rare shield with some life and resistances.
Step 4: Level 10
  • After killing Brutus, return to town.
  • Talk to Tarkleigh and grab Smoke Mine. This replaces Dash.
  • Click Purchase Items from Tarkleigh, then paste in the regex: -[rgb]-.-|g-g-g|nne
  • Complete the quests The Marooned Mariner and The Siren's Cadence.
    • Note: you do not need to kill Merveil to acquire a gem from The Siren's Cadence.
Step 5: Level 12
  • After killing Fairgraves and reaching the Waypoint in Merveil's Caverns, talk to Nessa for Poisonous Concoction.
    • Poisonous Concoction requires your main hand to be empty, so unequip your bow, and equip any type of shield that you have found so far. The skill consumes your Life Flask if possible to deal more damage, so keep up to date with your Life Flasks! You may see the most relevant Life flasks here. Lastly, the projectiles from Poisonous Concoction may overlap if the player has enough Area of Effect and number of projectiles. This becomes more relevant later on, when the character equips Greater Multiple Projectiles Support and Greater Volley Support.
  • Talk to Nessa and purchase Withering Step, Onslaught Support, and Volley Support.
    • Use Volley Support rather than Lesser Multiple Projectiles Support for more projectile damage. Replace Onslaught Support with Lesser Multiple Projectiles Support during boss fights
  • Talk to Bestel and grab the Passive Skillpoint, then complete The Siren's Cadence..
  • Equip a Sapphire Ring for Merveil to nullify her Cold Damage. Kill Merveil and move onto Act 2!


Pantheon Planner

For information about the Pantheon and how it works, don't hesitate to consult our Pantheon Guide!

For Major Pantheon, select Brine King to gain Immunity to Freeze and Reduction of Chill Effect. This bonus is not baseline and needs to be acquired with a Divine Vessel.

For Minor Pantheon, select Abberath and upgrade it. This grants you defences, but most importantly Immunity to Burning Ground.

Mapping Preparation

You're done with the Campaign and are ready to take on Path of Exile's Endgame. Priority 1 is capping your Elemental Resistances (75%) and having sufficient Attributes to continue leveling your Skill Gems. Use Essences you have gathered on any item that is not Magic or Rare already. Items with an open modifier slot can be crafted on. Head to the Crafting Bench and craft the Resistances you need and Life wherever else possible.

Map Modifiers

Avoid (or cautiously run) the following modifiers:

  • Avoid Chance to avoid Poison because you can't Poison frequently enough!
  • Avoid Enemies have +x% Chaos Resistance because it significantly decreases your damage!
  • Take care of -% to maximum Resistances because you then get destroyed by Elemental Damage!
  • Avoid Reduced Effect of Auras because it reduces your Armour and Evasion, making you vulnerable to attacks!

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