Leveling

Act 2

• Walk north into The Forest Encampment, sell all items you acquired from Merveil, then go to the right of town into The Old Fields and complete The Great White Beast.
  • Talk to Yeena and select the magic Quicksilver Flask reward.
  • At this point use two Life flasks, one Mana flask, and two Quicksilver Flasks.
• Waypoint back to The Crossroads, complete the Trial of Ascendancy and finish the quest Intruders in Black in the Chambers of Sin 2.
  • Make sure to complete the Trial of Ascendancy in the Chambers of Sin 2.
  • Talk to Greust and select the gem Herald of Agony.
  • Talk to Yeena and purchase the gems Summon Skitterbots and Blood Rage. If you are struggling with mana, you may remove Precision.
• Go left from the Town to complete the quest Sharp and Cruel in The Weaver's Chambers.
  • Talk to Silk and get the gem Faster Attacks Support. You can level this gem in your off-hand weapons.
• Complete the quest Deal with the Bandits.
  • Waypoint to the Crossroads, go right to the Broken Bridge, kill Kraityn, and return to town.
  • Waypoint to the Riverways, go north to The Wetlands, and kill Oak.
  • While in the Western Forest, kill Alira and complete the quest The Way Forward.
• After completing these quests, talk to Eramir for two Passive Skillpoints, then return to Lioneye's Watch to receive another Passive Skillpoint from Bestel.
• Complete the quest Shadow of the Vaal by killing the Act 2 boss, Vaal Oversoul. After this, return to town and complete the Trial of Ascendancy in The Crypt. Once these are done, move onto Act 3!

Act 2 Tips

• If you sell rare items identified they will give you Alteration Shards, while selling them unidentified gives you Transmutation Shards.
• Herald of Agony gives you 10% more Poison Damage, +20% chance to poison, and you gain a scorpion summon that will do damage to monsters. This damage increases as you apply more poisons in quick succession.
• Summon Skitterbots gives two small robot minions that run up to nearby monsters. One will chill nearby monsters and the other will shock them, slowing them and increasing damage taken respectively.
• Use a Ruby Ring for Vaal Ruins as the monsters casting Explosive Arrow are scary.

Act 3

• Waypoint to the City of Sarn, kill the Guard Captain, and talk to Clarissa. Complete Lost in Love.
  • Complete the Trial of Ascendancy and obtain Tolman's Bracelet.
  • Talk to Clarissa to obtain the Sewer Keys.
  • Talk to Maramoa and choose Despair.
• Complete the quests Victario's Secrets, The Ribbon Spool and The Gemling Queen.
  • Choose the rare Lapis Amulet as a reward.
  • Ensure that you complete the Trial of Ascendancy from The Catacombs at some point during this cycle.
• Complete the quests Sever the Right Hand and Piety's Pets.
• Aim for at least level 27 before killing Piety. After killing her, return to town.
  • Talk to Hargan for a Passive Skillpoint (from the quest Victario's Secrets).
  • Talk to Grigor to get a Passive Skillpoint.
• Complete the Trial of Ascendancy in The Imperial Gardens.
• While fighting Dominus, avoid getting slammed when he raises his fist. Kill Dominus and move on to Act 4!

Act 3 Tips

• Use Despair on magic and rare packs, and all boss encounters.
• Ignore the quest Sever the Right Hand. This build does not require you to kill Gravicius.
• Farm The Docks if you are behind in XP. You can reset a zone by holding down Ctrl and left clicking on either a zone entrance or Waypoint.
• Any of the two-stone ring bases, such as Two-Stone Ring, are the best type of rings you can equip. Despite this, always prioritize stats over basetype. For example, Coral Ring is superior to Two-Stone Ring
• Gems can level up in any socket, including your off-hand!
• Try to get your Fire, Cold, and Lightning resists close to 75%.
• The best crafts are from the Crafting Bench in your hideout. Use the 16-20% of a single resist craft, which only costs an Orb of Transmutation.

Act 4

• Complete the quest Breaking the Seal, and farm Dried Lake until at least level 30.
• Complete the quest An Indomitable Spirit.
• Reach the Waypoint in the Crystal Veins and complete the normal Labyrinth.
  • Ascend as an Trickster, and choose One Step Ahead.

Ascendancy

• One Step Ahead Increases your action speed to always be at least 108%, and monsters will always be at 92%. This causes monsters to be slightly slower, but always being at 108% action speed means that you will perform every action your character takes 8% faster. Every movement or attack you make will be slightly faster, and you cannot be frozen, chilled, or slowed down by Temporal Chains.
• Do not progress past Crystal Veins without being at least level 32. Farm Dried Lake if you need to catch up.
• Complete the quest The Eternal Nightmare by killing Daresso and Kaom.
• Kill Piety, then complete the quest Corpus Malachus.
• Talk to Piety again, go kill Malachai, and move on to Act five!

Act 4 Tips

• Act 4 is when the game strains your resistances, and playing below 75% is extremely dangerous. Start to overcap resists in this Act as you are aiming for at least 105% by the time you kill Act 5 Kitava.
• Keep identifying rare items to find high Life and Resistance gear.

Act 5

• Complete the quest Return to Oriath and talk to Lani for a ring matching the resists you need the most. A Two-Stone ring is superior to any of the single-resist rings as they are easier to replace later.
• Complete the quests In Service to Science, The Key to Freedom, and reach the Chamber of Innocence.
• Return to town and talk to Lani for a Jade Flask.
• Talk to Vilenta for a Passive Skillpoint.
• Complete the quest Death to Purity.
• Complete the quests The Ravenous God and Kitava's Torments.
• Kill Kitava, and move onto Act six!

Act 5 Tips

• Get at least 75% resists in Fire, Cold, and Lightning - but aim for 105%, as you lose 30% from killing Kitava.
  • Put every armor and jewelry piece you're using into the crafting bench in your hideout to see if it has space for a Fire, Cold, or Lightning resist craft. This is only usable if the item has an Open Suffix (hold Alt on an item to check). 
  • In softcore, it is acceptable if your elemental resistances are around 50%.
• Once you enter the Chamber of Innocence, farm this zone until at least level 40. You can reset a campaign zone by holding down CTRL and clicking on the zone or Waypoint.
• When Kitava closes his fist, he spawns orbs that hone in on your location in an X formation, exploding in the center. Avoid any slams and abilities from the large unique monsters that spawn.

Act 6

• Go out to The Coast and get the Waypoint, then go to the Mud Flats and complete the quest The Father of War.
• Once at the Ridge Waypoint, take it back to The Coast and complete Bestel's Epic.
• Use a Portal Scroll and complete Fallen From Grace.
  • Talk to Lily Roth for 2x Passive Respec Points. This vendor gives access to all gems in the game, and can be accessed from your hideout.
  • Talk to Bestel for either a rare Leather Belt or Agate Amulet, depending on which slot needs a bigger upgrade.
  • Talk to Tarkleigh for a Passive Skillpoint.
• Travel to The Lower Prison and complete the Trial of Ascendancy.
• Finish Essence of Umbra by killing Brutus and Shavronne.
• Kill Abberath in Prisoner's Gate for The Cloven One.
• Grab the Waypoint in The Riverways, then go north to The Wetlands and kill Ryslatha for The Puppet Mistress.
• Return to town and talk to Bestel for a Passive Skillpoint.
• Talk to Tarkleigh for a rare (4L helm) and a Passive Skillpoint.
• Complete the remaining questline to defeat The Brine King, then move onto Act 7.

Act 6 tips

• If entering Act 6 at 42, you don't need to farm any XP past this point until Act 9. Remain within 6 levels of your current zone.
• Entering this Act without 75% all resists is perfectly fine (in softcore!). The elemental damage you take here depends on which part of the Act you are in. The Mud Flats and the Tukohama fight requires Fire res, the Shavronne fight Lightning res, and the Brine King Cold and Lightning res. Using this, it’s okay if your resists initially look like 75% Fire, 50% Cold, and 50% Lightning (again, in softcore). In hardcore, ensure that all resists equal 75% or more.
• Go to your hideout and throw each piece individually at the crafting bench to see if you can craft a Fire, Cold, or Lightning resist on them for 1 Orb of Transmutation each. Obviously only craft the types of resists you need!
• You may skip Abberath and Ryslatha until late Act 7 if your character is too weak at this point.
• Select the Brine King Pantheon (the Keybind is Y by default) after killing The Brine King.

Act 7

• Complete the quest The Silver Locket.
• Travel to The Crypt for the Trial of Ascendancy and the map for Essence of the Artist.
• Waypoint back to The Crossroads, travel north to the Chamber of Sins, and complete Web of Secrets.
• Do the Trial of Ascendancy while in the Chambers of Sin 2, and complete The Master of a Million Faces.
• Gather the seven fireflies for the quest Lighting the Way, and kill Greust for the quest The Master of a Million Faces while in The Dread Thicket.
• Exit The Dread Thicket and travel to The Causeway for Kishara's Star.
• Get to the Waypoint in the Vaal City and talk to Yeena there, then return to town.
  • Select the Pantheon Ralakesh, Master of a Million Faces.
  • Talk to Eramir for two Passive Skillpoints.
  • Talk to Weylam Roth to select the Quartz Flask and a Passive Skillpoint.
  • Talk to Helena and select the rare Carnal Boots.
• After this, complete the Cruel Labyrinth.
• Completing Cruel Lab awards you with Polymath.
  • Polymath grants you bonuses for every unique mastery you have, such as Life Mastery. You will get the ascendancy perks once for having +50 Life, but you will not get another boost from Polymath for having +10% increased maximum Life. For each different type of mastery you have, you gain 3% more damage, and 1% Life, Energy Shield, and Mana gained on kill.
• Finally, Waypoint back to The Vaal City, travel to Temple of Decay 2, and kill Arakaali. Avoid the cone of poisonous bolts, as well as the purple orbs that spawn far away and travel towards the boss. After this, move onto Act 8!

Act 7 Tips

• A faster way to complete the cycle in late Act 7 after killing Greust is to place a portal outside of the Dread Thicket, go through The Causeway for Kishara's Star, get to the waypoint in Vaal City, then take the waypoint back to town and go through your portal. This is not included up above as portals expire if you are too slow.

Act 8

• Kill Doedre for the quest Essence of the Hag, then go to the right towards The Quay.
• Complete the quest Love is Dead, then travel to the Grain Gate to complete The Gemling Legion.
• Continue to the Solaris Temple and get the waypoint in Solaris Temple 1.
• Complete the quest Solar Eclipse and return to town.
  • Talk to Clarissa for a Passive Skillpoint.
  • Talk to Hargan for whichever Two-Stone ring reward you need the most.
  • Talk to Maramoa for a Passive Skillpoint.
• Go back to Solaris Temple 1, travel to the Solaris Concourse, through Harbour Bridge, then Lunaris Concourse.
• Go to the Lunaris Temple 2 and complete Lunar Eclipse.
• Travel to the Lunaris Concourse and kill the Twins Solaris the Eternal Sun and Lunaris the Eternal Eternal Moon.
  Stand behind Solaris when she throws her Fire Spear and move away when Lunaris fires Cold Rain from the Sky.
  Afterwards, continue onwards to Act 9 and the best zone in the campaign for farming - the Blood Aqueducts!

Act 9

• Farm the Blood Aqueducts until character level 64 for gear, gem levels, and currency.
  • Get your elemental resists to be close to 105% when killing Act 10 Kitava as you receive another 30% penalty to resistances. Mapping with ~60% resists is fine for softcore, but is a definite no-go in hardcore.
  • While farming Blood Aqueduct you might find Humility cards, which sell for approximately 2 Chaos Orb at the start of a league.
• Go back to Lunaris Concourse in Act 8 to get the Trail of Ascendancy in the Bath House and complete the Reflection of Terror in the High Gardens. Return to town and talk to Hargan for a Passive Skillpoint.
• Complete the quest The Storm Blade. Return to town then talk to Petarus and Vanja for an Alder Spiked Shield.
• Talk to Sin for the next quest item, then Petarus and Vanja again. Return back to the Vastiri Desert waypoint and complete the quest Queen of the Sands. Return to town and talk to Irasha for a Passive Skillpoint.
• Kill The Basilisk in the Boiling Lake.
• Complete the quest Fastis Fortuna.
• Complete the Trial of Ascendancy in The Tunnel.
• Complete the Ruler of Highgate, then return to town and talk to Irasha for a Passive Skillpoint.
• Finish the quest Recurring Nightmare by killing Act 9 boss The Depraved Trinity. Avoid the boss' slam, and avoid getting hit by the scorpion ads that spawn. Next, move onto Act 10!

Act 10

• Kill Plaguewing and complete the quest Safe Passage.
• Place a portal in the middle of the Ruined Square, and go to the waypoint in the Control Blocks (left).
• Take the waypoint back to town and talk to Lani in town for a Silver Flask.
  • This Flask gives a buff called Onslaught, which grants 20% increased attack, cast, and movement speed.
• Don't complete the quest Vilenta's Vengeance in the Control Blocks at this time if your character feels weak. Instead, go through your portal that you placed earlier and go to the right this time towards the Ossuary.
• Complete the quest No Love for Old Ghosts and the Trial of Ascendancy in the Ossuary.
• Complete the Merciless Labyrinth and choose Heartstopper.
  • Go a bit slower than normal in Merciless Labyrinth as there is a difficulty spike. Stop for dark shrines, and try to get extra keys if they are along your path. Merciless lab can provide a lot of currency and gear at this stage.
  • Heartstopper shifts between the player taking 40% less Damage from Hits and 40% less Damage over Time for 5 seconds. While it can unreliable, it will undoubtably increase the durability of your character.
• Kill Avarius to complete the quest Death and Rebirth, then return to town.
  • Talk to Bannon with the The Staff of Purity in your inventory.
  • Talk to Lani for a Zodiac Leather.
  • Talk to Weylam Roth for 2x Passive Respec Points.
• Travel back to the Ravaged Square, talk to Innocence, and complete the quest An End to Hunger.
• Kill Kitava, and move onto the mapping section below - congratulations on completing the campaign!
  • Note that killing Kitava reduces your overall resistances by 30% again. Prepare for this by obtaining gear with as high resists as possible. Aim for 75% Fire, Cold, and Lightning Resists for mapping.